Journal article

Remote ischaemic preconditioning reduces myocardial injury in patients undergoing heart valve surgery: randomised controlled trial

Xie J, Liao X, Chen W, Huang D, Chang F, Chen W, Luo Z, Wang Z, Ou J ...see all

Heart, vol. 98, issue 5 (2012) pp. 384-388

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OBJECTIVE: To determine whether remote ischaemic preconditioning (RIPC) is cardioprotective in patients undergoing heart valve replacement., DESIGN: Single-blinded, randomised controlled trial., SETTING: Tertiary referral hospital in China., PATIENTS: Adult patients (31-72 years) undergoing mitral valve, aortic valve or tricuspid valve surgery., INTERVENTIONS: Patients were randomised to either the RIPC (n=38) or control (n=35) group. After induction of anaesthesia, patients in the RIPC group underwent three 5 min cycles of right upper limb ischaemia, induced by an automated cuff-inflator placed on the upper arm and inflated to 200 mm Hg. Each cycle was interrupted by a 5 min period of reperfusion during which time the cuff was deflated. The control group had only a deflated cuff placed on the upper arm for 30 min., MAIN OUTCOME MEASURES: Serum troponin I concentration was measured before surgery and at 6, 12, 24, 48, and 72 h postoperatively. The cardiac function of all patients was followed postoperatively., RESULTS: Troponin I concentration was reduced in the RIPC group (398.7+/-179.3 mug/l) compared with the control group (708.4+/-242.5 mug/l). Mean difference was 309.7+/-50.8 (95% CI 210.1 to 409.3, p

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  • Jian-Jiang Xie

  • Xiao-Long Liao

  • Wen-Guang Chen

  • Da-De Huang

  • Feng-Jun Chang

  • Wen Chen

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