Renal cell carcinoma: recent advances in genetics and imaging.

  • Choudhary S
  • Sudarshan S
  • Choyke P
 et al. 
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Abstract

Recent advances in molecular biology and cytogenetics have provided
unique insights into the ontogeny, pathogenesis, and biological behavior
of renal cell carcinoma. Renal cell carcinoma is now known to be
a polymorphic malignant neoplasm consisting of several histologic
subtypes demonstrating different biological profiles. Clear cell
renal carcinoma, the most common histologic subtype, is predominantly
associated with mutations involving the von Hippel-Lindau gene and
elaboration of vascular and somatic growth factors. Clear cell renal
cell carcinoma is thus typically hypervascular at imaging. By contrast,
papillary renal cell carcinoma, the second most common subtype, is
frequently hypovascular. Current molecular data on the biology of
renal neoplasms have shown important diagnostic, therapeutic, and
prognostic implications. Comprehensive knowledge of molecular pathways
of carcinogenesis of renal cancers has allowed design of rational
treatment protocols and posttreatment surveillance algorithms, thereby
permitting optimal patient management.

Author-supplied keywords

  • Carcinoma
  • Renal Cell
  • X-Ray Computed
  • diagnosis/genetics; Contrast Media
  • diagnosis/genetics; Kidney
  • diagnostic use; Genetic Predisposition to Disease
  • genetics; Humans; Image Enhancement
  • methods
  • methods; Kidney Neoplasms
  • methods; Tomography
  • pathology/radiography; Magnetic Resonance Imaging

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  • PMID: 19711643

Authors

  • Shaile Choudhary

  • Sunil Sudarshan

  • Peter L Choyke

  • Srinivasa R Prasad

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