Renal drug metabolism.

  • Lohr J
  • Willsky G
  • Acara M
  • 121


    Mendeley users who have this article in their library.
  • 172


    Citations of this article.


I. Introduction A. History B. Methodology 1. Clearance. 2. Sperber technique in chickens. 3. Isolated perfused kidney. 4. Tissue Preparations. 5. Molecular biology. II. Renal Pathways for the Biotransformation of Drugs A. Cytochrome P450 Dependent Mixed Function Oxidase System 1. Cytochrome P450 in the kidney. 2. Drugs that induce cytochrome P450 proteins. 3. Specific renal cytochrome P450 enzymes. 4. Nondrug factors that affect cytochrome P450 enzymes in the kidney that may modulate kidney drug metabolism. B. N-Oxidation (Flavin-Containing Monooxygenases) C. Alcohol Oxidation D. Aldehyde Oxidation E. Oxidative Deamination (Monoamine Oxidase) F. Aldehyde and Ketone Reduction 1. Aldehyde reductase. 2. Ketone reductase. 3. Other. G. Hydrolysis Mechanisms 1. Ester and amide hydrolysis/carboxylesterase and amidase. 2. Epoxide hydrolysis. III. Phase II: Synthetic Conjugation Pathways A. Glucuronidation 1. Isoforms. 2. Substrates and kinetics. 3. Induction of renal glucuronyl transferase. 4. Localization. 5. Relative contribution of renal glucuronidation. B. Sulfation C. Methylation 1. N-methylation. 2. O-methylation. 3. S-methylation. D. Acetylation E. Glutathione Conjugation F. Mercapturic Acid Synthesis G. Amino Acid Conjugation 1. Glycine conjugation. 2. Glutamine conjugation. H. Cysteine Conjugate [beta]-Lyase IV. Localization of Drug Metabolizing Enzymes in the Kidney V. Effects of Renal Metabolism Acknowledgments References

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

  • SCOPUS: 2-s2.0-0031944651
  • PMID: 9549760
  • SGR: 0031944651
  • ISBN: 0031-6997
  • ISSN: 0031-6997
  • PUI: 28158844


  • J W Lohr

  • G R Willsky

  • M a Acara

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free