Renal outcomes among Egyptian lupus nephritis patients: A retrospective analysis of 135 cases from a single centre

  • G.A. M
  • H.S. Z
  • S.A. G
 et al. 
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Abstract

Objectives: The objective of this paper is to describe renal outcomes in a group of Egyptian patients with lupus nephritis and to identify variable prognostic factors. Patients and methods: The records of 135 patients (129 females, six males) with biopsy-proven lupus nephritis seen between 1999 and 2011 at Kasr Al-Aini Hospital, Cairo University, were reviewed and included in a retrospective analysis. Biopsies were classified according to the WHO classification. Renal outcomes were defined according to the Renal Subcommittee of Renal Insufficiency of the American College of Rheumatology. Results: The mean follow-up period was 55.64-25.68 (range 4-156) months. Thirty-nine patients (29.9%) developed an adverse final outcome. This composite outcome, defined as persistent elevation of serum creatinine ≥1.2 mg/dl, chronic renal insufficiency, end-stage renal disease or death, was seen in 12 (8.9%), seven (5.2%), three (2.2%) and 17 (12.6%) patients, respectively. The overall patient survival was 93.5% and 87.5% at five and 10 years, respectively. Factors associated with an adverse outcome included male gender (p=0.037), hypertension at nephritis onset (p=0.001), serum creatinine ≥1.2 mg/dl (p

Author-supplied keywords

  • Adolescent
  • Adult
  • Egypt
  • Female
  • Humans
  • Immunosuppressive Agents
  • Lupus Nephritis
  • Male
  • Prednisone
  • Retrospective Studies
  • Young Adult
  • article
  • azathioprine
  • cardiolipin antibody
  • complications
  • creatinine
  • creatinine blood level
  • creatinine clearance
  • cyclophosphamide
  • drug therapy
  • epidemiology
  • female
  • fibrosing alveolitis
  • follow up
  • glomerulosclerosis
  • human
  • human tissue
  • hypertension
  • kidney biopsy
  • lupus erythematosus nephritis
  • major clinical study
  • male
  • medical record review
  • methylprednisolone
  • mycophenolate mofetil
  • outcome assessment
  • prednisone
  • priority journal
  • remission
  • retrospective study
  • survival
  • survival rate
  • therapeutic use
  • thrombosis
  • urinary cast

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Authors

  • Mahmoud G.A.

  • Zayed H.S.

  • Ghoniem S.A.

  • G A Mahmoud

  • H S Zayed

  • S A Ghoniem

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