Repeated amphetamine administration alters AMPA receptor subunit expression in rat nucleus accumbens and medial prefrontal cortex.

  • Lu W
  • Wolf M
  • 3

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Abstract

Glutamate is critical for the induction and maintenance of behavioral sensitization and associated neuroadaptations in the mesocorticolimbic dopamine (DA) system. We have shown previously [Lu et al. (1997) Synapse 26:269-280] that repeated amphetamine administration alters AMPA receptor subunit mRNA levels in rat nucleus accumbens (NAc) and medial prefrontal cortex (PFC). The present study determined if amphetamine elicits corresponding changes in AMPA receptor subunit immunolabeling. Rats were injected with amphetamine sulphate (5 mg/kg/day) or saline for 5 days and perfused 3 or 14 days after the last injection. AMPA receptor subunit immunolabeling was quantified using autoradiographic immunocytochemistry. In the NAc, GluR1 and GluR2 immunolabeling were unchanged after 3 days of withdrawal, but both were decreased significantly after 14 days of withdrawal (GluR1, 85.5+/-2.6% of control group, P

Author-supplied keywords

  • Amphetamine
  • Amphetamine: pharmacology
  • Animals
  • Behavior, Animal
  • Behavior, Animal: physiology
  • Brain Chemistry
  • Brain Chemistry: drug effects
  • Dopamine Uptake Inhibitors
  • Dopamine Uptake Inhibitors: pharmacology
  • Gene Expression
  • Gene Expression: drug effects
  • Immunohistochemistry
  • Interneurons
  • Interneurons: chemistry
  • Interneurons: drug effects
  • Male
  • Nucleus Accumbens
  • Nucleus Accumbens: chemistry
  • Nucleus Accumbens: cytology
  • Nucleus Accumbens: drug effects
  • Prefrontal Cortex
  • Prefrontal Cortex: chemistry
  • Prefrontal Cortex: cytology
  • Prefrontal Cortex: drug effects
  • RNA, Messenger
  • RNA, Messenger: analysis
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, AMPA
  • Receptors, AMPA: analysis
  • Receptors, AMPA: genetics

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Authors

  • W Lu

  • M E Wolf

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