Resident microbiota affect bordetella pertussis infectious dose and host specificity

  • Weyrich L
  • Feaga H
  • Park J
 et al. 
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Before contacting host tissues, invading pathogens directly or indirectly interact with host microbiota, but the effects of such interactions on the initial stages of infection are poorly understood. Bordetella pertussis is highly infectious among humans but requires large doses to colonize rodents, unlike a closely related zoonotic pathogen, Bordetella bronchiseptica, raising important questions about the contributions of bacterial competition to initial colonization and host selection. We observed that

Author-supplied keywords

  • Bordetella
  • antibiotics
  • bacterial competition
  • host adaptation
  • interspecies competition
  • microbiome
  • pathogen evolution
  • whooping cough

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  • Laura S. Weyrich

  • Heather A. Feaga

  • Jihye Park

  • Sarah J. Muse

  • Chetan Y. Safi

  • Olivier Y. Rolin

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