Respiratory syncytial virus prevention and therapy: Past, present, and future

  • M. W
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Respiratory syncytial virus (RSV) is the most common respiratory pathogen in infants and young children worldwide. More than 50 years after its discovery, and despite relentless attempts to identify pharmacological therapies to improve the clinical course and outcomes of this disease, the most effective therapy remains supportive care. Although the quest for a safe and effective vaccine remains unsuccessful, pediatricians practicing during the past decade have been able to protect at least the more vulnerable patients with safe and effective passive prophylaxis. This review summarizes the history, microbiology, epidemiology, pathophysiology, and clinical manifestations of this infection in order to provide the reader with the background information necessary to fully appreciate the many challenges presented by the clinical management of young children with bronchiolitis. The last part of this article attempts an evidence-based review of the pharmacologic strategies currently available and those being evaluated, intentionally omitting highly experimental approaches not yet tested in clinical trials and, therefore, not likely to become available in the foreseeable future. © 2010 Wiley-Liss, Inc.

Author-supplied keywords

  • *Paramyxovirus
  • *Respiratory syncytial pneumovirus
  • *antibody
  • *apnea
  • *asthma
  • *bronchiolitis
  • *bronchiolitis/dm [Disease Management]
  • *bronchiolitis/dt [Drug Therapy]
  • *pneumonia
  • *prevention
  • *respiratory syncytial virus infection/dm [Disease
  • *respiratory syncytial virus infection/dt [Drug Th
  • *respiratory syncytial virus infection/ep [Epidemi
  • *respiratory syncytial virus infection/et [Etiolog
  • *respiratory syncytial virus infection/pc [Prevent
  • *therapy
  • *wheezing
  • adrenalin/dt [Drug Therapy]
  • antibiotic agent/dt [Drug Therapy]
  • antivirus agent/dt [Drug Therapy]
  • beclometasone dipropionate/ct [Clinical Trial]
  • beclometasone dipropionate/dt [Drug Therapy]
  • beta adrenergic receptor stimulating agent/dt [Dru
  • bronchiolitis/dt [Drug Therapy]
  • bronchodilating agent/dt [Drug Therapy]
  • child
  • chronic disease
  • clinical feature
  • clinical trial
  • corticosteroid/dt [Drug Therapy]
  • corticosteroid/ih [Inhalational Drug Administratio
  • deoxyribonuclease/dt [Drug Therapy]
  • dexamethasone/ct [Clinical Trial]
  • dexamethasone/dt [Drug Therapy]
  • dexamethasone/po [Oral Drug Administration]
  • disease course
  • drug half life
  • drug mechanism
  • drug structure
  • drug therapy
  • epidemiology
  • evidence based practice
  • heliox/dt [Drug Therapy]
  • human
  • immune response
  • immunoglobulin/dt [Drug Therapy]
  • immunoprophylaxis
  • incidence
  • infant
  • infection
  • ipratropium bromide/dt [Drug Therapy]
  • leukotriene
  • mast cell
  • microbiology
  • montelukast/ct [Clinical Trial]
  • montelukast/dt [Drug Therapy]
  • motavizumab/an [Drug Analysis]
  • motavizumab/ct [Clinical Trial]
  • motavizumab/dt [Drug Therapy]
  • motavizumab/im [Intramuscular Drug Administration]
  • neuroimmunology
  • nonhuman
  • oxygen therapy
  • palivizumab/ct [Clinical Trial]
  • palivizumab/dt [Drug Therapy]
  • palivizumab/im [Intramuscular Drug Administration]
  • palivizumab/pd [Pharmacology]
  • palivizumab/pk [Pharmacokinetics]
  • pathogenesis
  • pathophysiology
  • patient
  • pediatrician
  • placebo
  • priority journal
  • prophylaxis
  • reading
  • respiratory syncytial virus antibody/dt [Drug Ther
  • respiratory syncytial virus infection/dt [Drug The
  • respiratory syncytial virus vaccine/dt [Drug Thera
  • review
  • ribavirin/ct [Clinical Trial]
  • ribavirin/dt [Drug Therapy]
  • salbutamol/dt [Drug Therapy]
  • sodium chloride/dt [Drug Therapy]
  • surfactant/dt [Drug Therapy]
  • vaccine XT - bronchiolitis / drug therapy / adren
  • virus replication
  • virus transmission

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  • Wright M.

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