Resveratrol directly binds to mitochondrial complex i and increases oxidative stress in brain mitochondria of aged mice

  • Gueguen N
  • Desquiret-Dumas V
  • Leman G
 et al. 
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Abstract

Resveratrol is often described as a promising therapeutic molecule for numerous diseases, especially in metabolic and neurodegenerative disorders. While the mechanism of action is still debated, an increasing literature reports that resveratrol regulates the mitochondrial respiratory chain function. In a recent study we have identified mitochondrial complex I as a direct target of this molecule. Nevertheless, the mechanisms and consequences of such an interaction still require further investigation. In this study, we identified in silico by docking study a binding site for resveratrol at the nucleotide pocket of complex I. In vitro, using solu- bilized complex I, we demonstrated a competition between NAD+ and resveratrol. At low doses (

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Authors

  • Naïg Gueguen

  • Valérie Desquiret-Dumas

  • Géraldine Leman

  • Stéphanie Chupin

  • Stéphanie Baron

  • Valérie Nivet-Antoine

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