Retinal remodeling during retinal degeneration

  • Jones B
  • Marc R
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Abstract

Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural retina. As in other central nervous system degenerations, deafferentation activates remodeling. Neuronal remodeling is the common fate of all photoreceptor degenerations. © 2005 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Amacrine cell
  • Bipolar cell
  • Computational molecular phenotyping
  • GHL
  • Ganglion cell
  • Horizontal cell
  • P23H
  • Photoreceptor
  • Plasticity
  • RCS
  • Remodeling
  • Retina
  • S334ter
  • TG9N
  • nrJ
  • orJ
  • pcd
  • rd1
  • rd2
  • rdcl
  • retinitis pigmentosa
  • rhoΔCTA

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