Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural retina. As in other central nervous system degenerations, deafferentation activates remodeling. Neuronal remodeling is the common fate of all photoreceptor degenerations. © 2005 Elsevier Ltd. All rights reserved.
CITATION STYLE
Jones, B. W., & Marc, R. E. (2005, August). Retinal remodeling during retinal degeneration. Experimental Eye Research. https://doi.org/10.1016/j.exer.2005.03.006
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