Retrograde axonal transport: pathways to cell death?

  • Perlson E
  • Maday S
  • Fu M
 et al. 
  • 15


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Active transport along the axon is crucial to the neuron. Motor-driven transport supplies the distal synapse with newly synthesized proteins and lipids, and clears damaged or misfolded proteins. Microtubule motors also drive long-distance signaling along the axon via signaling endosomes. Although positive signaling initiated by neurotrophic factors has been well-studied, recent research has focused on stress-signaling along the axon. Here, the connections between axonal transport alterations and neurodegeneration are discussed, including evidence for defective transport of vesicles, mitochondria, degradative organelles, and signaling endosomes in models of amyotrophic lateral sclerosis, Huntington's, Parkinson's and Alzheimer's disease. Defects in transport are sufficient to induce neurodegeneration, but recent progress suggests that changes in retrograde signaling pathways correlate with rapidly progressive neuronal cell death.

Author-supplied keywords

  • *Nerve Degeneration/metabolism/pathology/physiopat
  • *Neurodegenerative Diseases/pathology/physiopathol
  • Animals
  • Axonal Transport/*physiology
  • Cell Death/*physiology
  • Humans
  • Microtubules/metabolism
  • Molecular Motor Proteins/*metabolism
  • Neurons/cytology/physiology
  • Signal Transduction/*physiology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in


  • E Perlson

  • S Maday

  • M M Fu

  • A J Moughamian

  • E L Holzbaur

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free