Retrograde Flow and Shear Rate Acutely Impair Endothelial Function in Humans

  • Thijssen D
  • Dawson E
  • Tinken T
 et al. 
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Abstract

Changes in arterial shear stress induce functional and structural vasculature adaptations. Recent studies indicate that substantial retrograde flow and shear can occur through human conduit arteries. In animals, retrograde shear is associated with atherogenic effects. The aim of this study was to examine the impact of incremental levels of retrograde shear on endothelial function in vivo. On 3 separate days, we examined bilateral brachial artery flow-mediated dilation, an index of NO-mediated endothelial function, in healthy men (24+/-3 years) before and after a 30-minute intervention consisting of cuff inflation to 25, 50, or 75 mm Hg. Cuff inflations resulted in "dose"-dependent increases in retrograde shear rate, compared with the noncuffed arm, within subjects (P

Author-supplied keywords

  • Echo Doppler
  • Endothelial function
  • Oscillatory
  • Retrograde shear stress
  • Shear stress pattern

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Authors

  • Dick H J Thijssen

  • Ellen A. Dawson

  • Toni M. Tinken

  • N. Timothy Cable

  • Daniel J. Green

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