RIG-I "Sees" the 5'-triphosphate

  • Zheng C
  • Wu H
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Abstract

RIG-I protects host cells against various RNA viruses by sensing viral RNAs in the cytoplasm. Crystal structures of RIG-I C-terminal domain bound to 5'-triphosphate dsRNA unveils how RIG-I recognizes the 5'-triphosphate moiety, a hallmark of viral RNAs (Lu et al., 2010). © 2010 Elsevier Ltd.

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