RIGUI, a putative mammalian ortholog of the Drosophila period gene

  • Sun Z
  • Albrecht U
  • Zhuchenko O
 et al. 
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Abstract

The molecular components of mammalian circadian clocks are elusive. We have isolated a human gene termed RIGUI that encodes a bHLH/PAS protein 44% homologous to Drosophila period. The highly conserved mouse homolog (m- rigui) is expressed in a circadian pattern in the suprachiasmatic nucleus (SCN), the master regulator of circadian clocks in mammals. Circadian expression in the SCN continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of m-rigui expression in the SCN. m-rigui transcripts also appear in a periodic pattern in Purkinje neurons, pars tuberalis, and retina, but with a timing of oscillation different from that seen in the SCN. Sequence homology and circadian patterns of expression suggest that RIGUI is a mammalian orthology of the Drosophila period gene, raising the possibility that a regulator of circadian clocks is conserved.

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Authors

  • Zhong Sheng Sun

  • Urs Albrecht

  • Olga Zhuchenko

  • Jennifer Bailey

  • Gregor Eichele

  • Cheng Chi Lee

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