The risk of adverse events associated with atropine administration during dobutamine stress echocardiography in cardiac transplant patients: a 28-year single-center experience

  • Wang Ji J
  • Ye S
  • Haythe J
 et al. 
  • 3

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

BACKGROUND: Although dobutamine stress echocardiography (DSE) is performed in heart transplant patients, the safety profile of atropine administration in DSE in this setting is unclear. METHODS AND RESULTS: We identified heart transplant patients who received atropine during DSE from January 1984 to August 2011 at our institution and compared them with a propensity-scored matched control group of heart transplant patients who underwent DSE without atropine. Adverse events were defined as significant arrhythmias (sinus arrest, Mobitz type II heart block, complete heart block, ventricular tachycardia, or ventricular fibrillation), hypotension requiring hospitalization, syncope or presyncope, myocardial infarction, and death. Forty-five heart transplant patients (median age 62 years, 82% male) received 0.2-1 mg atropine during DSE. Of these, 1 patient (2.2%) developed temporary complete heart block. No adverse events were identified in the control group of 154 patients who received dobutamine without atropine. CONCLUSIONS: Our findings suggest that complete heart block can occur infrequently with the administration of atropine in heart transplant patients undergoing DSE. Therefore, patients should be appropriately monitored for these adverse events during and after DSE.Copyright © 2013 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • *Atropine/ad [Administration & Dosage]
  • *Atropine/ae [Adverse Effects]
  • *Dobutamine/ad [Administration & Dosage]
  • *Dobutamine/du [Diagnostic Use]
  • *Echocardiography, Stress/td [Trends]
  • *Heart Transplantation/td [Trends]
  • 3S12J47372 (Dobutamine)
  • 7C0697DR9I (Atropine)
  • Aged
  • Aged, 80 and over
  • Drug Therapy, Combination
  • Echocardiography, Stress/ae [Adverse Effects]
  • Female
  • Follow-Up Studies
  • Heart Block/ci [Chemically Induced]
  • Heart Block/di [Diagnosis]
  • Heart Transplantation/ae [Adverse Effects]
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk Factors

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • J Wang Ji

  • S Ye

  • J Haythe

  • P C Schulze

  • D Shimbo

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free