Risk of cerebrovascular events in persons with and without HIV: A Danish nationwide population-based cohort study

  • Rasmussen L
  • Engsig F
  • Christensen H
 et al. 
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OBJECTIVE:: To assess the risk of cerebrovascular events (CVE) in HIV-infected individuals and evaluate the impact of proven risk factors, injection drug abuse (IDU), immunodeficiency, highly active antiretroviral therapy (HAART) and family-related risk factors. DESIGN:: Nationwide, population-based cohort study METHODS:: The study population included all Danish HIV-infected individuals, a population based comparison cohort and parents of both cohorts - all with no prior cerebral comorbidity. We computed incidence rate ratios (IRR) of overall CVE and CVE with and without proven risk factors, stratifying the analyses on IDU. Impact of immunodeficiency, HAART, protease-inhibitors, indinavir, didanosin, tenofovir and abacavir on risk of CVE was analyzed using time-dependent Cox regression analyses. RESULTS:: HIV-infected individuals had an increased risk of CVE compared with the comparison cohorts {(non-IDU HIV adjusted IRR 1.60; 95% CI: 1.32-1.94), (IDU HIV adjusted IRR 3.94; 95% CI: 2.16-7.16)}. The risk was increased with and without proven risk factors. A CD4 count

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  • Line D Rasmussen

  • Frederik Neess Engsig

  • Hanne Christensen

  • Jan Gerstoft

  • Gitte Kronborg

  • Court Pedersen

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