Risk factors for perinatal arterial ischaemic stroke in full-term infants: A case-control study

  • Harteman J
  • Groenendaal F
  • Kwee A
 et al. 
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OBJECTIVE: The incidence of perinatal arterial ischaemic stroke (PAIS) is about 1 in 2300 live births. Evidence about the aetiology is still lacking. The aim of this study was to identify maternal, perinatal and neonatal risk factors for symptomatic PAIS in full-term infants.

METHODS: Each full-term infant with PAIS was matched to three healthy controls for gestational age, date of birth and hospital of birth. Antenatal and perinatal risk factors were studied using univariate and multivariate conditional logistic regression analysis.

RESULTS: Fifty-two infants were diagnosed with PAIS. Significant risk factors in the univariate analysis (p38°C) during delivery (10% vs 1%), fetal heart rate decelerations (63% vs 16%), meconium-stained amniotic fluid (44% vs 17%), emergency caesarean section (35 vs 2%), Apgar score (1 min) ≤3 (29% vs 1%), Apgar score (5 min)
CONCLUSIONS: Maternal fever during delivery and early-onset sepsis/meningitis were found to be involved with PAIS as was previously noted. Apgar score (5 min)

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  • Floris GroenendaalUniversity Medical Center Utrecht

  • Johanna C. Harteman

  • Anneke Kwee

  • Paco M J Welsing

  • Manon J N L Benders

  • Linda S. De Vries

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