Risk factors for subclinical carotid atherosclerosis among current smokers

  • Johnson H
  • Piper M
  • Jorenby D
 et al. 
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This study characterized the determinants of carotid atherosclerosis in a large contemporary sample of current smokers. Associations between risk factors, carotid intima-media thickness (CIMT), and carotid plaque presence were determined by multivariable regression. Participants included 1504 current smokers (58% female) who were a median (interquartile range) of 44.7 (38-53) years old and smoked 25 (15-40) pack-years; 55% had plaque. Pack-years, age, male sex, nonwhite race, body mass index, systolic blood pressure, small low-density lipoproteins (LDLs), and total high-density lipoproteins were independently associated with CIMT (model R(2) =0.434, P

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  • Heather M. Johnson

  • Megan E. Piper

  • Douglas E. Jorenby

  • Michael C. Fiore

  • Timothy B. Baker

  • James H. Stein

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