Risperidone and clozapine combination for the treatment of refractory schizophrenia

  • Morera A
  • Barreiro P
  • Cano-Munoz J
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Clozapine is the most widely used antipsychotic drug for the treatment of refractory schizophrenia. Here we report the case of two residual schizophrenic patients refractory to conventional antipsychotics who showed a poor response to atypical antipsychotics. The combination of risperidone and clozapine produced a noticeable improvement in the patients' clinical status and a shortening of the treatment response latency.

Author-supplied keywords

  • Adult
  • Clozapine/*therapeutic use
  • Drug Therapy, Combination
  • Humans
  • Male
  • Middle Aged
  • Risperidone/*therapeutic use
  • Schizophrenia/*drug therapy

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  • A L Morera

  • P Barreiro

  • J L Cano-Munoz

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