The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse

  • Yan X
  • Kuipers F
  • Havekes L
 et al. 
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Abstract

We evaluated the role of apolipoprotein E (apoE) in the clearance of neutral and negatively charged liposomes by hepatocytes in apoE-deficient mice. Negatively charged liposomes were cleared at identical rates in apoE-deficient and wild-type mice; neutral liposomes were cleared at a 3.6-fold slower rate in apoE-deficient mice. ApoE deficiency did not affect hepatic uptake of negatively charged liposomes but lowered that of neutral liposomes >5-fold. Hepatocyte uptake of neutral liposomes was reduced >20-fold in apoE-deficient mice; that of negatively charged liposomes remained unchanged. We conclude that uptake of neutral liposomes by hepatocytes is nearly exclusively apoE-mediated. © 2005 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • Apolipoprotein E-deficient mice
  • Hepatocytes
  • Liposome opsonization

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Authors

  • Xuedong Yan

  • Folkert Kuipers

  • Louis M. Havekes

  • Rick Havinga

  • Bert Dontje

  • Klaas Poelstra

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