Role of Assay Type in Determining Free 25-Hydroxyvitamin D Levels in Diverse Populations

  • Nielson C
  • Jones K
  • Chun R
 et al. 
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To the Editor: It is unclear whether circulating free or bioavailable 25-hydroxyvitamin D is a better marker of vitamin D status than is total 25-hydroxyvitamin D, especially in racially diverse populations. Until recently, the only method to compare the levels was to estimate the level of free or bioavailable 25-hydroxyvitamin D from total 25-hydroxyvitamin D, vitamin D-binding protein (also known as gc-globulin, encoded by the GC gene), and albumin, with or without the GC genotype. Powe et al. reported that levels of vitamin D-binding protein, as measured on a monoclonal enzyme-linked immunosorbent assay (ELISA, R&D Systems), were lower in black . . .

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  • Carrie M. Nielson

  • Kerry S. Jones

  • Rene F. Chun

  • Jon Jacobs

  • Ying Wang

  • Martin Hewison

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