To the Editor: It is unclear whether circulating free or bioavailable 25-hydroxyvitamin D is a better marker of vitamin D status than is total 25-hydroxyvitamin D, especially in racially diverse populations. Until recently, the only method to compare the levels was to estimate the level of free or bioavailable 25-hydroxyvitamin D from total 25-hydroxyvitamin D, vitamin D-binding protein (also known as gc-globulin, encoded by the GC gene), and albumin, with or without the GC genotype. Powe et al. reported that levels of vitamin D-binding protein, as measured on a monoclonal enzyme-linked immunosorbent assay (ELISA, R&D Systems), were lower in black . . .
CITATION STYLE
Nielson, C. M., Jones, K. S., Chun, R. F., Jacobs, J., Wang, Y., Hewison, M., … Orwoll, E. S. (2016). Role of Assay Type in Determining Free 25-Hydroxyvitamin D Levels in Diverse Populations. New England Journal of Medicine, 374(17), 1695–1696. https://doi.org/10.1056/nejmc1513502
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