The role of autoimmune regulator (Aire) in the development of the immune system

Abstract

AIRE is the gene responsible for a rather rare hereditary type of autoimmune disease. The mechanism underlying the autoimmune pathogenesis caused by AIRE deficiency is a focus of intense research because it could provide clues to the fundamental question of how the immune system discriminates between self and non-self within the thymic microenvironment. © 2009 Elsevier Masson SAS. All rights reserved.