Excitatory synapses in the brain show several forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), which are initiated by increases in intracellular Ca2+ that are generated through NMDA (N-methyl-D-aspartate) receptors or voltage-sensitive Ca 2+ channels. LTP depends on the coordinated regulation of an ensemble of enzymes, including Ca2+/calmodulin-dependent protein kinase II, adenylyl cyclase 1 and 8, and calcineurin, all of which are stimulated by calmodulin, a Ca2+-binding protein. In this review, we discuss the hypothesis that calmodulin is a central integrator of synaptic plasticity and that its unique regulatory properties allow the integration of several forms of signal transduction that are required for LTP and LTD.
CITATION STYLE
Xia, Z., & Storm, D. R. (2005, April). The role of calmodulin as a signal integrator for synaptic plasticity. Nature Reviews Neuroscience. https://doi.org/10.1038/nrn1647
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