Role of chelates in treatment of cancer.

  • Tripathi L
  • Kumar P
  • Singhai A
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Abstract

Chelates are used in cancer as cytotoxic agent, as radioactive agent in imaging studies and in radioimmunotherapy. Various chelates based on ruthenium, copper, zinc organocobalt, gold, platinum, palladium, cobalt, nickel and iron are reported as cytotoxic agent. Monoclonal antibodies labeled with radioactive metals such as yttrium-90, indium-111 and iodine-131 are used in radioimmunotherapy. This review is an attempt to compile the use of chelates as cytotoxic drugs and in radioimmunotherapy.

Author-supplied keywords

  • Animals
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal: therapeutic use
  • Antineoplastic Agents
  • Antineoplastic Agents: therapeutic use
  • Cell Growth Processes
  • Cell Growth Processes: drug effects
  • Cell Growth Processes: radiation effects
  • Chelating Agents
  • Chelating Agents: therapeutic use
  • Chelation Therapy
  • Chelation Therapy: trends
  • Cytotoxins
  • Cytotoxins: therapeutic use
  • Drug Therapy
  • Drug Therapy: trends
  • Humans
  • Mice
  • Neoplasms
  • Neoplasms: drug therapy
  • Neoplasms: pathology
  • Neoplasms: radiotherapy
  • Radioimmunotherapy
  • Radioimmunotherapy: trends
  • Radioisotopes
  • Radioisotopes: therapeutic use
  • Rats
  • Treatment Outcome

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Authors

  • Laxmi Tripathi

  • Praveen Kumar

  • a K Singhai

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