Role of CYP1A2 polymorphisms on lung cancer risk in a prospective study

  • Pavanello S
  • Fedeli U
  • Mastrangelo G
 et al. 
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Abstract

Cytochrome P4501A2 (CYP1A2) is a key enzyme for lung carcinogen activation and lung inflammation. We studied the interactions of the CYP1A2 functional variants -3860. G/A(rs2069514),-2467. T/delT(rs3569413),-163C/A(rs762551)] with occupational/environmental carcinogenic exposures in the development of lung cancer in a case-control study nested in the Danish prospective cohort " Diet, Cancer and Health." At enrollment (1993-1997), blood samples for genotype analyses and information on lifestyle were collected 5 (mean value) years before the onset of the disease. The study population included 425 lung cancer cases and 786 subcohort members, who were gender- and age-matched. We found that -163A carriers were at increased risk of lung cancer (P= 0.035) in a multivariate COX regression model, which was adjusted for personal habits (i.e., cumulative smoking, passive smoke at home, alcohol intake, and fruit intake) and occupational exposure. Additionally, the interaction between -2467delT and smoking increases lung cancer risk in males, especially light smokers (

Author-supplied keywords

  • CYP1A2 polymorphism
  • Carcinogen exposure
  • Europeans
  • Inflammation
  • Lung cancer
  • Prospective study

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