The role of ESCRT proteins in attenuation of cell signalling

  • Rodahl L
  • Stuffers S
  • Lobert V
 et al. 
  • 40

    Readers

    Mendeley users who have this article in their library.
  • 20

    Citations

    Citations of this article.

Abstract

The ESCRT (endosomal sorting complex required for transport) machinery consists of four protein complexes that mediate sorting of ubiquitinated membrane proteins into the intraluminal vesicles of multivesicular endosomes, thereby targeting them for degradation in lysosomes. In the present paper, we review how ESCRT-mediated receptor down-regulation affects signalling downstream of Notch and growth factor receptors, and how ESCRTs may control cell proliferation, survival and cytoskeletal functions and contribute to tumour suppression.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Lina M. Rodahl

  • Susanne Stuffers

  • Viola H. Lobert

  • Harald Stenmark

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free