Role of fibroblast subpopulations in periodontal physiology and pathology

  • McCulloch C
  • Bordin S
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Abstract

Fibroblasts are the principal cell type in the soft connective tissues of the periodontium; they perform important functions in development, physiology, and disease. A growing number of reports have indicated site-specific phenotypic variation of fibroblasts. Heterogeneity of metabolic traits has been demonstrated in cells from healthy and diseased tissues. The tissue distribution and relative proportions of fibroblast subpopulations have a significant impact on the regulation of connective tissue function in health and disease.

Author-supplied keywords

  • fibroblast
  • pathology
  • physiology

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Authors

  • Christopher A.G. McCulloch

  • Sandra Bordin

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