Role of the JNK signal transduction pathway in inflammatory bowel disease

  • Roy P
  • Rashid F
  • Bragg J
 et al. 
  • 26

    Readers

    Mendeley users who have this article in their library.
  • 51

    Citations

    Citations of this article.

Abstract

The c-Jun NH2-terminal Kinase (JNK) pathway represents one sub-group of the mitogen-activated protein (MAP) kinases which plays an important role in various inflammatory diseases states, including inflammatory bowel disease (IBD). Significant progress towards understanding the function of the JNK signaling pathway has been achieved during the past few years. Blockade of the JNK pathway with JNK inhibitors in animal models of IBD lead to resolution of intestinal inflammation. Current data suggest specific JNK inhibitors hold promise as novel therapies in IBD.

Author-supplied keywords

  • Inflammation
  • Inflammatory bowel disease
  • JNK pathway

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free