The role of melatonin in parasite biology

  • Bagnaresi P
  • Nakabashi M
  • Thomas A
 et al. 
  • 49


    Mendeley users who have this article in their library.
  • 14


    Citations of this article.


Regarded as the circadian hormone in mammals, melatonin is a highly conserved molecule, present in nearly all species. In this review, we discuss the role of this indolamine and its precursors in the cell biology of parasites and the role of the molecule in the physiology of the host. In Plasmodium, melatonin can modulate intracellular concentrations of calcium and cAMP, which in turn can regulate kinase activity and cell cycle. In Trypanosoma infections, modulation of the immune system by melatonin is extremely important in controlling the parasite population. Melatonin also contributes to the inflammatory response to Toxoplasma gondii infection. Thus, there are a number of unique adaptations involving intricate connections between melatonin and the biology of the parasite-host relationship. © 2011 Elsevier B.V.

Author-supplied keywords

  • Circadian rhythm
  • Malaria
  • Melatonin
  • Plasmodium chabaudi, Calcium signaling
  • Plasmodium falciparum

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Piero Bagnaresi

  • Myna Nakabashi

  • Andrew P. Thomas

  • Russel J. Reiter

  • Célia R.S. Garcia

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free