A role for phosphorylated Pol II CTD in modulating transcription coupled histone dynamics

  • Spain M
  • Govind C
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Abstract

Histone acetylation modulates histone occupancy both at promoters and in coding sequences. Based on our recent observation that HDACs in the budding yeast, Saccharomyces cerevisiae, are co-transcriptionally recruited to coding regions by elongating polymerases, we propose a model in which Pol II facilitates recruitment of chromatin remodeling complexes as well as other factors required for productive elongation.

Author-supplied keywords

  • GCN4
  • HATs
  • HDACs
  • Histone acetyltransferase
  • Histone deacetylases
  • Kin28
  • RNA polymerase II
  • RSC
  • Transcription
  • Yeast

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Authors

  • Marla M. Spain

  • Chhabi K. Govind

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