The role of the serotonergic system in foot shock-induced behavior in mice

  • Roliński Z
  • Herbut M
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Abstract

In a foot shock-induced fighting (FSIF) test, serotonergic and antiserotonergic agents were examined. Stimulation of the brain 5-hydroxytryptamine (5-HT) neurons with different serotonergic agents, such as l-tryptophan, 5-hydroxytryptophan, imipramine, fluoxetine, 5-methoxy-tryptamine, quipazine, and fenfluramine, showed the inhibiting role of the 5-HT system in FSIF. At the same time, following the results obtained in FSIF tests and locomotor activity tests, it can be inferred that the 5-HT antagonists used (methysergide, cyproheptadine, metergoline, cinnarizine, and pizotifen) do not act specifically in this model of aggression. P-Chlorophenylalanine effects on mice in FSIF also seem to be partly due to catecholaminolytic action.

Author-supplied keywords

  • Aggressive behavior
  • Foot shock-induced fighting
  • Mice
  • Serotonergic and antiserotonergic agents

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Authors

  • Z. Roliński

  • M. Herbut

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