Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines

  • Jiang S
  • Li R
  • Du L
 et al. 
  • 37


    Mendeley users who have this article in their library.
  • 16


    Citations of this article.


Seasonal influenza epidemics and influenza pandemics caused by influenza A virus (IAV) has resulted in millions of deaths in the world. The development of anti-IAV vaccines and therapeutics is urgently needed for prevention and treatment of IAV infection and for controlling future influenza pandemics. Hemagglutinin (HA) of IAV plays a critical role in viral binding, fusion and entry, and contains the major neutralizing epitopes. Therefore, HA is an attractive target for developing anti-IAV drugs and vaccines. Here we have reviewed the recent progress in study of conformational changes of HA during viral fusion process and development of HA-based antiviral therapeutics and vaccines.

Author-supplied keywords

  • antiviral drugs
  • hemagglutinin
  • influenza A virus
  • vaccines
  • viral entry

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free