The safety of dextromethorphan in pregnancy: Results of a controlled study

  • Einarson A
  • Lyszkiewicz D
  • Koren G
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Abstract

Dextromethorphan (DM), the d-isomer of the codeine analog levorphanol, is an active ingredient present in a variety of cough and cold remedies. Recently, data generated from a study in chick embryos were extrapolated to suggest that pregnant women should not use this drug because of the risk of birth defects. We conducted a controlled study of pregnant women who used DM, to examine the possible teratogenic risk in humans.

Author-supplied keywords

  • Birth defects
  • Dextromethorphan
  • Pregnancy

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Authors

  • A. Einarson

  • D. Lyszkiewicz

  • G. Koren

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