This study examines the efficacy, safety, and tolerability of a nasal spray to induce anesthesia of maxillary teeth. Forty-five healthy adults requiring restoration of one maxillary tooth were randomized in a 1:2 ratio to receive (1) an intra-oral lidocaine-epinephrine injection with buffered saline nasal spray bilaterally, or (2) a tetracaine hydrochloride-oxymetazoline hydrochloride nasal spray bilaterally with sham injection. Primary endpoints were use of rescue anesthesia and patient global pain assessment. Secondary outcomes included vital sign changes, soft-tissue anesthesia, and treatment-emergent adverse events. In intent-to-treat analysis, 25 of 30 patients given nasal spray (83.3%) did not require rescue anesthesia. Proportion of anesthesia successes for nasal spray was significantly different from the hypothesized placebo anesthesia success of 30% (one-sided p value
CITATION STYLE
Ciancio, S. G., Hutcheson, M. C., Ayoub, F., Pantera, E. A., Pantera, C. T., Garlapo, D. A., … Almubarak, S. A. (2013). Safety and Efficacy of a Novel Nasal Spray for Maxillary Dental Anesthesia. Journal of Dental Research, 92, S43–S48. https://doi.org/10.1177/0022034513484334
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