Salivary Gland Tissue Engineering and Repair

  • Pradhan-Bhatt S
  • Cannon K
  • Zakheim D
 et al. 
  • 9


    Mendeley users who have this article in their library.
  • 2


    Citations of this article.


Oral homeostasis is severely compromised upon salivary gland atrophy, which occurs after radiation therapy in head and neck cancer patients. Salivary gland hypofunction typically leads to xerostomia, dysphagia, dental caries, and other oropharyngeal infections, reducing the quality of life in afflicted patients [. 70]. Currently, xerostomia has no cure. Palliative therapies such as oral sialagogues and saliva substitutes only improve mild cases of xerostomia. Generation of a functional, tissue-engineered salivary gland will benefit patients suffering from xerostomia. Engineering of glandular tissue requires several essential components, including primary cells that retain biomarkers typical of the native gland, extracellular matrix proteins that can orchestrate the differentiation of primary cells into functional structures, and a scaffold that can hold these components together and recreate the microenvironment found in native glandular tissue. Additionally, vascularization and innervation must reach the implant for it to survive and function in vivo.

Author-supplied keywords

  • Hyaluronic acid
  • Hydrogels
  • Regenerative medicine
  • Salivary glands
  • Scaffolds
  • Tissue engineering
  • Xerostomia

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Swati Pradhan-Bhatt

  • Kevin Cannon

  • Daniel Zakheim

  • Daniel A. Harrington

  • Randall L. Duncan

  • Xinqiao Jia

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free