Salivary Gland Tissue Engineering and Repair

3Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Oral homeostasis is severely compromised upon salivary gland atrophy, which occurs after radiation therapy in head and neck cancer patients. Salivary gland hypofunction typically leads to xerostomia, dysphagia, dental caries, and other oropharyngeal infections, reducing the quality of life in afflicted patients [. 70]. Currently, xerostomia has no cure. Palliative therapies such as oral sialagogues and saliva substitutes only improve mild cases of xerostomia. Generation of a functional, tissue-engineered salivary gland will benefit patients suffering from xerostomia. Engineering of glandular tissue requires several essential components, including primary cells that retain biomarkers typical of the native gland, extracellular matrix proteins that can orchestrate the differentiation of primary cells into functional structures, and a scaffold that can hold these components together and recreate the microenvironment found in native glandular tissue. Additionally, vascularization and innervation must reach the implant for it to survive and function in vivo.

Cite

CITATION STYLE

APA

Pradhan-Bhatt, S., Cannon, K., Zakheim, D., Harrington, D. A., Duncan, R. L., Jia, X., … Witt, R. L. (2015). Salivary Gland Tissue Engineering and Repair. In Stem Cell Biology and Tissue Engineering in Dental Sciences (pp. 613–623). Elsevier Inc. https://doi.org/10.1016/B978-0-12-397157-9.00050-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free