Saturated fatty acids and insulin resistance

  • Funaki M
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Insulin resistance is one of the pathophysiological features of obesity and type 2 diabetes. Recent findings have linked insulin resistance to chronic low-grade inflammation in white adipose tissue. Excess storage of saturated fat in white adipose tissue due to a modern life style causes hypertrophy and hyperplasia of adipocytes, which exhibit attenuated insulin signaling due to their production and release of saturated fatty acids. These adipocytes recruit macrophages to white adipose tissue and, together with them, initiate a proinflammatory response. Proinflammatory factors and saturated fatty acids secreted into the bloodstream from white adipose tissue impair insulin signaling in non-adipose tissues, which causes whole-body insulin resistance

Author-supplied keywords

  • 2
  • ACID
  • Acids
  • Adipocyte
  • Adipose
  • Adipose tissue
  • Article
  • Hyperplasia
  • Hypertrophy
  • Inflammation
  • Insulin Resistance
  • Japan
  • Life Style
  • Macrophages
  • Obesity
  • Research
  • Resistance
  • Tissue
  • Tissues
  • Type 2 Diabetes
  • Universities
  • White Adipose Tissue
  • adipocytes
  • diabetes
  • fat
  • fatty acid
  • fatty acids
  • insulin
  • insulin-resistance
  • macrophage

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

  • PMID: 19763019


  • M Funaki

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free