The SCF ubiquitin ligase: insights into a molecular machine

  • Cardozo T
  • Pagano M
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Abstract

Ubiquitin ligases are well suited to regulate molecular networks that operate on a post-translational timescale. The F-box family of proteins - which are the substrate-recognition components of the Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase - are important players in many mammalian functions. Here we explore a unifying and structurally detailed view of SCF-mediated proteolytic control of cellular processes that has been revealed by recent studies.

Author-supplied keywords

  • Animals
  • Cell Cycle/physiology
  • Cyclin-Dependent Kinases/metabolism
  • Drug Design
  • Evolution, Molecular
  • F-Box Proteins/classification/genetics/*metabolism
  • Humans
  • Models, Molecular
  • Protein Structure, Tertiary
  • SKP Cullin F-Box Protein Ligases/chemistry/genetic

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Authors

  • T Cardozo

  • M Pagano

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