Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain

  • Richards A
  • Jones L
  • Moskvina V
 et al. 
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Abstract

It is widely thought that alleles that influence susceptibility to common diseases, including schizophrenia, will frequently do so through effects on gene expression. As only a small proportion of the genetic variance for schizophrenia has been attributed to specific loci, this remains an unproven hypothesis. The International Schizophrenia Consortium (ISC) recently reported a substantial polygenic contribution to that disorder, and that schizophrenia risk alleles are enriched among single-nucleotide polymorphisms (SNPs) selected for marginal evidence for association (P

Author-supplied keywords

  • GWAS
  • eQTL
  • genetics
  • polygenic score
  • polymorphism
  • schizophrenia

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