The secreted secret of PCSK9

  • Lou K
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... Proprotein convertase subtilisin kexin type 9 (PCSK9) is highly expressed in the liver. The protease first emerged as a hypercholesterolemia target in 2003 after a gene-association study showed that individuals with gain-of-function mutations in PCSK9 had higher levels of plasma low-density lipoprotein (LDL) cholesterol than normal individuals.2 Conversely, people with loss-of-function mutations had lower plasma LDL levels and a decreased risk of coronary artery disease (CAD) than normal individuals.3 ...

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  • Kai-Jye Lou

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