Selective one-pot synthesis of symmetrically and unsymmetrically substituted amines via rhodium catalysed multiple alkylations of ammonia or primary amines under hydroformylation conditions

  • Rische T
  • Kitsos-Rzychon B
  • Eilbracht P
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Abstract

Symmetrically and unsymmetrically substituted secondary and tertiary amines are selectively prepared in high yields by a one-pot multiple alkylation procedure from ammonia or primary amines with styrenes and/or cyclic olefins, carbon monoxide and hydrogen in the presence of [Rh(cod)Cl]2 as catalyst. Similarly unsymmetrically substituted tertiary amines are obtained under hydroformylation conditions from primary amines by a one-pot reductive bisalkylation procedure using preformed aldehydes or ketones in one step and the hydroformylation products in the second step of a combined amine condensation - reduction - hydroaminomethylation reaction sequence.

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Authors

  • Thorsten Rische

  • Beate Kitsos-Rzychon

  • Peter Eilbracht

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