Sensitivity comparison of surface plasmon resonance and plasmon-waveguide resonance biosensors

  • Abbas A
  • Linman M
  • Cheng Q
  • 50


    Mendeley users who have this article in their library.
  • 43


    Citations of this article.


Plasmon-waveguide resonance (PWR) sensors are particularly useful for the investigation of biomolecular interactions with or within lipid bilayer membranes. Many studies demonstrated their ability to provide unique qualitative information, but the evaluation of their sensitivity as compared to other surface plasmon resonance (SPR) sensors has not been broadly investigated. We report here a comprehensive sensitivity comparison of SPR and PWR biosensors for the p-polarized light component. The sensitivity of five different biosensor designs to changes in refractive index, thickness and mass are determined and discussed. Although numerical simulations show an increase of the electric field intensity by 30-35% and the penetration depth by four times in PWR, the waveguide-based method is 0.5-8-fold less sensitive than conventional SPR in all considered analytical parameters. The experimental results also suggest that the increase in the penetration depth in PWR is made at the expense of the surface sensitivity. The physical and structural reasons for PWR sensor limitations are discussed and a general viewpoint for designing more efficient SPR sensors based on dielectric slab waveguides is provided. © 2011 Elsevier B.V.

Author-supplied keywords

  • Optical biosensors
  • Planar waveguide
  • Plasmon-waveguide resonance
  • Surface plasmon resonance
  • Surface sensitivity

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Abdennour Abbas

  • Matthew J. Linman

  • Quan Cheng

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free