Sequential chemoimmunotherapy of experimental visceral leishmaniasis using a single low dose of liposomal amphotericin B and a novel DNA vaccine candidate

  • Seifert K
  • Juhls C
  • Salguero F
 et al. 
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Abstract

Combination therapies for leishmaniasis, including drugs and immunomodulators, are one approach to shorten treatment courses and to improve the treatment of complex manifestations of the disease. We evaluated a novel T-cell-epitope-enriched DNA vaccine candidate (LEISHDNAVAX) as host-directed immunotherapy in combination with a standard antileishmanial drug in experimental visceral leishmaniasis. Here we show that the DNA vaccine candidate can boost the efficacy of a single suboptimal dose of liposomal amphotericin B in C57BL/6 mice.

Author-supplied keywords

  • Amphotericin B/*therapeutic use
  • Animals
  • Antiprotozoal Agents/*therapeutic use
  • Female
  • Immunotherapy/methods
  • Leishmaniasis, Visceral/*drug therapy
  • Mice
  • Mice, Inbred C57BL
  • Vaccines, DNA/*therapeutic use

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Authors

  • K Seifert

  • C Juhls

  • F J Salguero

  • S L Croft

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