Seroprevalence of human papillomavirus type 16 in children

  • Dunne E
  • Karem K
  • Sternberg M
 et al. 
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Abstract

We evaluated the prevalence of antibodies to human papillomavirus ({HPV}) type 16 in a representative sample of children 6-11 years of age in the United States. Serum samples and questionnaire data were collected between 1991 and 1994, for the National Health and Nutrition Examination Survey {III}. {HPV}-16-specific immunoglobulin G antibodies were detected by an {HPV}-16 L1 virus-like particle-based enzyme-linked immunosorbant assay. Overall, 2.4% of 1316 children 6-11 years of age were seropositive. Seroprevalence was higher in boys than in girls (3.5% vs. 1.2%; P=.08) and in children {\textgreater}7 years of age than in children {\textless} or =7 years of age (3.3% vs. 0.4%; P{\textless}.05). None of the variables tested for, including race/ethnicity, socioeconomic status, and urban or rural residence, were significantly associated with {HPV}-16 seropositivity. To explain {HPV}-16 seropositivity in this population, further study is required.

Author-supplied keywords

  • Age Factors
  • Antibodies
  • Child
  • Continental Population Groups
  • Ethnic Groups
  • Female
  • Humans
  • Male
  • Papillomaviridae
  • Papillomavirus Infections
  • Rural Population
  • Seroepidemiologic Studies
  • Socioeconomic Factors
  • United States
  • Urban Population
  • Viral

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Authors

  • Eileen F Dunne

  • Kevin L Karem

  • Maya R Sternberg

  • Katherine M Stone

  • Elizabeth R Unger

  • William C Reeves

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