Serotonin, inflammation, and IBS: Fitting the jigsaw together?

  • Spiller R
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Abstract

Unexplained diarrhoea is a frequent indication for gastroenterologic referral, and after full investigation the most common final diagnosis is irritable bowel syndrome (IBS). Some patients with IBS describe an acute onset of symptoms following infective gastroenteritis. Postinfective IBS affects 7% to 31% of individuals infected, and appears to be a nonspecific response to injury which has been reported following Salmonella-, Campylobacter-, and Shigella-related IBS. The strongest risk factor for developing postinfective IBS is severity of the initial diarrhoea illness, but toxigenicity of the infected bacteria, age

Author-supplied keywords

  • Infection
  • Inflammation
  • Irritable bowel syndrome
  • Serotonin

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Authors

  • Robin Spiller

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