Serum carbonic anhydrase 9 level is associated with postoperative recurrence of conventional renal cell cancer

  • Li G
  • Feng G
  • Gentil-Perret A
 et al. 
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Abstract

PURPOSE: We explored the clinical usefulness of serum carbonic anhydrase 9 as a potential biomarker for conventional renal cell cancer. MATERIALS AND METHODS: This study included 91 patients with conventional renal cell cancer and 32 healthy individuals. Enzyme linked immunosorbent assay was used to measure the carbonic anhydrase 9 level. A followup (median 38 months) was performed to track early recurrence after surgery for patients with localized disease. Recurrence-free survival curves were calculated by the Kaplan-Meier method and compared using the log rank test. RESULTS: The mean serum carbonic anhydrase 9 level in patients with metastatic conventional renal cell cancer (216.68 +/- 67.02 pg/ml) or localized conventional renal cell cancer (91.65 +/- 13.29 pg/ml) was significantly higher than in healthy individuals (14.59 +/- 6.22 pg/ml, p

Author-supplied keywords

  • *Antigens, Neoplasm/bl [Blood]
  • *Biomarkers, Tumor/bl [Blood]
  • *Carbonic Anhydrases/bl [Blood]
  • *Carcinoma, Renal Cell/en [Enzymology]
  • *Kidney Neoplasms/en [Enzymology]
  • *Neoplasm Recurrence, Local/bl [Blood]
  • *Neoplasm Recurrence, Local/mo [Mortality]
  • 0 (Antigens, Neoplasm)
  • 0 (Biomarkers, Tumor)
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Biopsy, Needle
  • Carbonic Anhydrase IX
  • Carcinoma, Renal Cell/mo [Mortality]
  • Carcinoma, Renal Cell/pa [Pathology]
  • Carcinoma, Renal Cell/su [Surgery]
  • Cohort Studies
  • Disease-Free Survival
  • EC 4-2-1-1 (CA9 protein, human)
  • EC 4-2-1-1 (Carbonic Anhydrase IX)
  • EC 4-2-1-1 (Carbonic Anhydrases)
  • Female
  • Humans
  • Immunohistochemistry
  • Kidney Neoplasms/mo [Mortality]
  • Kidney Neoplasms/pa [Pathology]
  • Kidney Neoplasms/su [Surgery]
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local/et [Etiology]
  • Neoplasm Recurrence, Local/pa [Pathology]
  • Neoplasm Staging
  • Nephrectomy/ae [Adverse Effects]
  • Nephrectomy/mt [Methods]
  • Postoperative Complications
  • Prognosis
  • Proportional Hazards Models
  • ROC Curve
  • Risk Assessment
  • Sensitivity and Specificity
  • Statistics, Nonparametric
  • Survival Analysis
  • Treatment Outcome

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  • PMID: 18550116

Authors

  • G Li

  • G Feng

  • A Gentil-Perret

  • C Genin

  • J Tostain

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