Serum concentrations of fibroblast growth factor 19 in patients with obesity and type 2 diabetes mellitus: the influence of acute hyperinsulinemia, very-low calorie diet and PPAR-α agonist treatment.

  • Mráz M
  • Lacinová Z
  • Kaválková P
 et al. 
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The aim of our study was to measure serum concentrations of fibroblast growth factor 19 (FGF-19) in patients with obesity (OB), obesity and type 2 diabetes mellitus (T2DM) and healthy subjects (C) at baseline and after selected interventions. We measured serum FGF-19 levels and other biochemical and hormonal parameters in 29 OB and 19 T2DM females and 30 sex- and age-matched control subjects. The interventions were acute hyperinsulinemia during isoglycemic-hyperinsulinemic clamp (n=11 for T2DM and 10 for C), very-low calorie diet (VLCD, n=12 for OB) and 3 months treatment with PPAR-alpha agonist fenofibrate (n=11 for T2DM). Baseline serum FGF-19 levels were significantly lower in OB relative to C group (132.1+/-12.7 vs. 202.2+/-16.7 pg/ml, p

Author-supplied keywords

  • Acute Disease
  • Adult
  • Biological Markers
  • Biological Markers: blood
  • Blood Glucose
  • Blood Glucose: metabolism
  • Caloric Restriction
  • Caloric Restriction: methods
  • Diabetes Mellitus, Type 2
  • Diabetes Mellitus, Type 2: blood
  • Diabetes Mellitus, Type 2: therapy
  • Female
  • Fenofibrate
  • Fenofibrate: pharmacology
  • Fenofibrate: therapeutic use
  • Fibroblast Growth Factors
  • Fibroblast Growth Factors: blood
  • Humans
  • Hyperinsulinism
  • Hyperinsulinism: blood
  • Hyperinsulinism: therapy
  • Insulin Resistance
  • Middle Aged
  • Obesity
  • Obesity: blood
  • PPAR alpha
  • PPAR alpha: agonists
  • PPAR alpha: physiology
  • Treatment Outcome

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  • M Mráz

  • Z Lacinová

  • P Kaválková

  • D Haluzíková

  • P Trachta

  • J Drápalová

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