Serum quinidine concentrations and effect on QT dispersion and interval

  • Mathis A
  • Gandhi A
  • Lugo S
 et al. 
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OBJECTIVE: To establish a relationship between serum quinidine concentrations (SQCs) and QT interval dispersion, compared with corresponding QT intervals, in order to identify a reason why many reports describe torsade de pointes as occurring at subtherapeutic concentrations. DESIGN: Retrospective study. SETTING: University teaching hospital. PARTICIPANTS: Eleven patients with atrial arrhythmias managed with quinidine therapy. MAIN OUTCOME MEASURES: Patients with subtherapeutic (

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  • Quinidine
  • Torsade de pointes

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  • A. Scott Mathis

  • Ashesh J. Gandhi

  • Sonia I. Lugo

  • Esthel Rochefort

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