Photoperiod was hypothesized to mediate T cell-dependent B cell production of IgM and IgG. Antigens induced production of specific immunoglobulins; serum IgM but not IgG, was higher in males in long vs. short days (16 vs. 8 h light/day) and similarly among all groups of females. A second immunization with KLH robustly enhanced serum IgM, as well as IgG; increases were blunted in short- vs. long-day males but not in females. Thus, in male but not female hamsters, winter-like short days restrain aspects of primary and secondary humoral immune responses to xenoantigens. Actions on lymphocyte activities or clonal expansion are in considerations. © 2002 Elsevier Science B.V. All rights reserved.
CITATION STYLE
Hadley, A. R., Tran, L. T., Fagoaga, O. R., Nehlsen-Cannarella, S. L., & Yellon, S. M. (2002). Sex differences in photoperiod control of antigen-specific primary and secondary humoral immunity in Siberian Hamsters. Journal of Neuroimmunology, 128(1–2), 39–48. https://doi.org/10.1016/S0165-5728(02)00144-3
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