Sex differences in photoperiod control of antigen-specific primary and secondary humoral immunity in Siberian Hamsters

  • Hadley A
  • Tran L
  • Fagoaga O
 et al. 
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Photoperiod was hypothesized to mediate T cell-dependent B cell production of IgM and IgG. Antigens induced production of specific immunoglobulins; serum IgM but not IgG, was higher in males in long vs. short days (16 vs. 8 h light/day) and similarly among all groups of females. A second immunization with KLH robustly enhanced serum IgM, as well as IgG; increases were blunted in short- vs. long-day males but not in females. Thus, in male but not female hamsters, winter-like short days restrain aspects of primary and secondary humoral immune responses to xenoantigens. Actions on lymphocyte activities or clonal expansion are in considerations. © 2002 Elsevier Science B.V. All rights reserved.

Author-supplied keywords

  • Circadian rhythm
  • IgG
  • IgM
  • KLH
  • Pineal
  • Sheep erythrocytes

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  • Allison R. Hadley

  • Long T. Tran

  • Omar R. Fagoaga

  • Sandra L. Nehlsen-Cannarella

  • Steven M. Yellon

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